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To enhance psychological adjustment, Vipassana meditation assists individuals to perceive the transitory nature of the self. Because the consequences of this potentially troubling insight are not well understood, changes in self-concept and ego defense mechanisms of two cohorts (N1=222, N2=216) of young (M = 18.03 years) Thai participants who attended separate seven-day Vipassana meditation retreats and a nontreated control group (N = 281) were compared. Multivariate statistical analysis revealed positive gains in all areas of self-representation among meditators relative to controls (p < .001). Ego defense mechanisms of the meditation participants also underwent significant change (p < .0001) with coping becoming characterized by greater maturity and tolerance of common stressors. Increases in Buddhist beliefs were significantly correlated with heightened self-esteem and less impulsiveness (ps < .001). Theoretical and applied implications of the findings are discussed.