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State anxiety, somatization of stress, quality of life, self-rated quality of sleep, and discomfort due to over-breathing which occurs when stressed were studied. Out of a total of 140 participants, seventy participants self-selected to be in a yoga group for stress relief (group mean age +/- SD, 33.0 +/- 6.5 years; 37 males). Seventy age and gender matched participants were in a control group. State anxiety, somatization of stress, quality of life, discomfort and self-rated quality of sleep were assessed using the State-Trait Anxiety Inventory, Symptom Checklist-90-R, SF-12, Nijmegen Discomfort Evaluation Scale and a Sleep Rating Questionnaire respectively. Assessments were made at the beginning and end of the week. Repeated measures ANOVAs with Bonferroni adjusted post-hoc analyses showed a significant decrease in state anxiety (P < 0.001), somatization of stress (P < 0.01), improved health-related quality of life (P < 0.01), self-rated quality of sleep (P < 0.01), and decrease in discomfort due to over-breathing (P < 0.001). No changes (except decreased discomfort due to over-breathing; P < 0.01) occurred in the control group. This study suggests that a brief yoga program may be beneficial in decreasing anxiety, somatization of stress and discomfort, improving health-related quality of life and self-rated sleep quality.